Preparation and quality control of lutetium-177 bleomycin as a possible therapeutic agent
نویسندگان
چکیده
Bleomycins are tumor seeking antibiotics that are widely used in cancer chemotherapy (Fig. 1). It is believed that bleomycin antibiotics interfere with DNA as false nucleotides, assuming the dithiazole moiety acts like a purine base [20]. It has been shown that labeling of bleomycin with bi/trivalent radioisotopes can produce pharmacologically active compounds carrying a diagnostic and/or therapeutic radioisotope depending on the decay type [12]. The measurements of oxidation-reduction potential of various metal-bleomycins suggested that the potentials were within a range that would allow the reduction of metal-bleomycin to take place in a cell [14]. Thus the incorporation of the whole complex into cells is possible, especially at high thiol levels for many tumor cells containing metallothioproteins, while most of the metal-BLM complexes are reportedly kinetically and thermodynamically stable in ligand substitution processes and are only slowly reduced and dissociated by sulfhydryl reagents. All these data support the possibility of development of an interesting metal radionuclide with therapeutic properties such as lutetium-177. Physicochemical properties of bleomycin trivalent lanthanide ion complexes have been already studied Preparation and quality control of lutetium-177 bleomycin as a possible therapeutic agent Hassan Yousefnia, Amir R. Jalilian, Samaneh Zolghadri, Ali Bahrami-Samani, Simindokht Shirvani-Arani, Mohammad Ghannadi-Maragheh
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